Department of Pharmaceutical, Chemical & Environmental Sciences, School of Science, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
Colloids Surf B Biointerfaces. 2013 Mar 1;103:99-106. doi: 10.1016/j.colsurfb.2012.10.006. Epub 2012 Oct 13.
Lyophilized muco-adhesive wafers with optimum drug loading for potential buccal delivery have been developed. A freeze-annealing cycle was used to obtain optimized wafers from aqueous gels containing 2% κ-carrageenan (CAR 911), 4% pluronic acid (F127), 4.4% (w/w) polyethylene glycol with 1.8% (w/w) paracetamol or 0.8% (w/w) ibuprofen. Thermogravimetric analysis showed acceptable water content between 0.9 and 1.5%. Differential scanning calorimetry and X-ray diffraction showed amorphous conversion for both drugs. Texture analysis showed ideal mechanical and mucoadhesion characteristics whilst both drugs remained stable over 6 months and drug dissolution at a salivary pH showed gradual release within 2h. The results show the potential of CAR 911 and F127 based wafers for buccal mucosa drug delivery.
已经开发出具有最佳药物负载的冻干粘弹性薄片，可用于潜在的颊部给药。通过冷冻退火循环，从含有 2%κ-卡拉胶（CAR 911）、4%泊洛沙姆（F127）、4.4%（w/w）聚乙二醇和 1.8%（w/w）对乙酰氨基酚或 0.8%（w/w）布洛芬的水性凝胶中获得优化的薄片。热重分析显示，水分含量在 0.9%到 1.5%之间是可以接受的。差示扫描量热法和 X 射线衍射表明两种药物均发生无定形转化。质地分析显示出理想的机械和粘膜粘附特性，而两种药物在 6 个月内均保持稳定，在唾液 pH 值下的药物溶出显示出 2 小时内的逐渐释放。结果表明，基于 CAR 911 和 F127 的薄片具有用于颊黏膜药物递送的潜力。
