“核”雌激素受体含量对子宫体早期癌预后的影响。短期随访。
Influence of "nuclear" estrogen receptor content on prognosis of early stage carcinoma of the uterine body. A short-time follow-up.
作者信息
Horvath G, Johnsson J E, Tropé C, Samuelsson L, Alm P, Olsson H
机构信息
Gynecologic Section, University Hospital, Lund, Sweden.
出版信息
Neoplasma. 1990;37(1):43-6.
Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and those with tumors containing greater than 60 fmol ER/mg DNA (p = 0.01). Other prognostic factors showed no differences in frequency of relapses. In this small patient material with a short-time follow-up we therefore suggest that ER in the nuclear pellet may be an important prognostic factor.
对65例I期和II期子宫内膜癌患者进行了研究。经过短期随访（17 - 24个月），观察到核沉淀物中雌激素受体含量低（雌激素受体少于60 fmol/mg DNA）的肿瘤患者与雌激素受体含量大于60 fmol/mg DNA的肿瘤患者之间复发频率存在显著差异（p = 0.01）。其他预后因素在复发频率上未显示出差异。因此，在这个短期随访的小样本患者资料中，我们认为核沉淀物中的雌激素受体可能是一个重要的预后因素。
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