Russ M, Fischer P A
Abteilung für Neurologie, J. W. Goethe-Universität, Frankfurt, Main.
Nervenarzt. 1990 Feb;61(2):88-93.
Patients with Parkinson's disease (n = 81) are compared with normal controls and three clinical groups, each representing a different level of cerebral impairment (TIA; Stroke; Alzheimer's disease (AD) and multi-infarct dementia (MID). Psychometric measures of abstract reasoning, speed of information processing, verbal and visual memory, visuospatial perception and psychomotor functions are taken using a neuropsychological test battery with appropriate age-correction and normalized scaling. Following differentiation between the uncomplicated idiopathic Parkinson's syndrome and Parkinson plus (signs of cerebral polypathy and/or a degenerative process exceeding the nigro-striatal system) the neuropsychological profile reveals intellectual impairments approaching the dementia level (AD/MID) only in the Parkinson plus subgroup. With the exception of the severe motor deficiencies, the overall performance of patients with an uncomplicated Parkinson's syndrome is largely on the level of age-matched controls. Slight deficits exist only in the speed of information processing (action under time restriction) and in visuoconstructive performance.
将帕金森病患者(n = 81)与正常对照组以及三个临床组进行比较,每个临床组代表不同程度的脑损伤(短暂性脑缺血发作;中风;阿尔茨海默病(AD)和多发梗死性痴呆(MID))。使用经过适当年龄校正和标准化量表的神经心理测试组合,对抽象推理、信息处理速度、言语和视觉记忆、视觉空间感知和心理运动功能进行心理测量。在区分单纯性特发性帕金森综合征和帕金森叠加综合征(脑多病变和/或超过黑质纹状体系统的退行性过程的体征)之后,神经心理学概况显示,仅在帕金森叠加综合征亚组中存在接近痴呆水平(AD/MID)的智力损伤。除严重运动缺陷外,单纯性帕金森综合征患者的总体表现很大程度上与年龄匹配的对照组相当。仅在信息处理速度(限时行动)和视觉构建表现方面存在轻微缺陷。