一种用于活细胞中钙离子的新型比率型荧光探针。
A novel ratiometric emission probe for Ca2+ in living cells.
机构信息
Research Center of Environmental Science and Engineering, and School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China.
出版信息
Org Biomol Chem. 2013 Jan 21;11(3):503-8. doi: 10.1039/c2ob26888d. Epub 2012 Nov 30.
A ratiometric fluorescent probe for Ca(2+) based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca(2+) over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca(2+) concentration in living human umbilical vein endothelial cells.
一种基于 1,3,4-噁二唑衍生物的比率型荧光探针已经被设计和开发出来。该探针具有较大的斯托克斯位移（202nm）和对 Ca(2+)的高选择性比率型发射响应（490/582nm），而对其他金属阳离子则没有响应。此外，该探针可以很容易地揭示活的人脐静脉内皮细胞内 Ca(2+)浓度的变化。
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