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一只2周龄葡萄牙水犬的先天性腺垂体发育不全伴继发性甲状腺功能减退

Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog.

作者信息

Gal Arnon, Raetzman Lori T, Singh Kuldeep

机构信息

Department of Pathobiology, University of Illinois, Urbana, Illinois, USA.

出版信息

Can Vet J. 2012 Jun;53(6):659-64.

PMID:23204587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3354827/
Abstract

This report describes the histomorphological changes of central hypothyroidism (pituitary dependent) in several target organs of thyroid hormones of a Portuguese water dog, and contrasts those with the reported features of central hypothyroidism in German shepherd dogs, in which central hypothyroidism is a part of a combined pituitary hormonal deficiency.

摘要

本报告描述了一只葡萄牙水犬甲状腺激素的几个靶器官中中枢性甲状腺功能减退（垂体依赖性）的组织形态学变化，并将这些变化与德国牧羊犬中枢性甲状腺功能减退的报告特征进行了对比，在德国牧羊犬中，中枢性甲状腺功能减退是垂体激素联合缺乏的一部分。

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本文引用的文献

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Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.对 71 例联合垂体激素缺乏症患者的 6 个垂体转录因子基因的突变和基因拷贝数分析：发现 1 例 LHX4 缺失患者。
J Clin Endocrinol Metab. 2010 Aug;95(8):4043-7. doi: 10.1210/jc.2010-0150. Epub 2010 Jun 9.
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A novel mutation (V101A) of the LHX4 gene in a Japanese patient with combined pituitary hormone deficiency.一名日本联合垂体激素缺乏症患者中LHX4基因的新型突变（V101A）
Exp Clin Endocrinol Diabetes. 2010 Jul;118(7):405-9. doi: 10.1055/s-0029-1225612. Epub 2009 Oct 23.
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The molecular basis of hypopituitarism.垂体功能减退症的分子基础。
Trends Endocrinol Metab. 2009 Dec;20(10):506-16. doi: 10.1016/j.tem.2009.06.005. Epub 2009 Oct 23.
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Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies.LHX4基因内的三个新错义突变与可变垂体激素缺乏症相关。
J Clin Endocrinol Metab. 2008 Mar;93(3):1062-71. doi: 10.1210/jc.2007-1525. Epub 2007 Dec 11.
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Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.LHX3和LHX4 LIM同源结构域因子在垂体发育中的作用。
Mol Cell Endocrinol. 2007 Feb;265-266:190-5. doi: 10.1016/j.mce.2006.12.019. Epub 2007 Jan 8.
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Pituitary transcription factors: from congenital deficiencies to gene therapy.垂体转录因子：从先天性缺陷到基因治疗
J Neuroendocrinol. 2006 Sep;18(9):633-42. doi: 10.1111/j.1365-2826.2006.01461.x.
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The molecular actions of thyroid hormone in bone.甲状腺激素在骨骼中的分子作用。
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Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.Lhx4和Prop1是垂体原基细胞存活和扩张所必需的。
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