Robinson W F, Shaw S E, Stanley B, Wyburn R S
School of Veterinary Studies, Murdoch University, Western Australia.
Aust Vet J. 1988 Dec;65(12):386-9. doi: 10.1111/j.1751-0813.1988.tb14279.x.
Two Scottish Deerhound puppies had clinical and pathological features consistent with the diagnosis of congenital non-goitrous hypothyroidism. They were from separate litters, but were the progeny of the same sire and dam. The puppies were smaller, had shorter limbs and shorter, broader heads than their littermates. They also had histories of weakness, difficulty in walking and somnolence. A characteristic radiographic feature was the absence of epiphyseal growth centres. Both had depressed serum thyroxine (T4) levels and one did not respond to exogenous thyroid stimulating hormone. On necropsy, the thyroid glands were small, the follicles varied in size and contained little or no colloid. The adenohypophysis contained many cells with markedly vacuolated cytoplasm. It is suggested that the clinicopathological pattern is the result of a primary thyroid abnormality. Possible mechanisms include either primary thyroid hypoplasia or an unresponsiveness to thyroid stimulating hormone.
两只苏格兰猎鹿犬幼犬具有与先天性非甲状腺肿性甲状腺功能减退症诊断相符的临床和病理特征。它们来自不同的窝，但都是同一父本和母本的后代。与同窝幼犬相比，这两只幼犬体型较小，四肢较短，头部更短更宽。它们还有虚弱、行走困难和嗜睡的病史。一个典型的放射学特征是没有骨骺生长中心。两只幼犬的血清甲状腺素（T4）水平均降低，其中一只对外源性促甲状腺激素无反应。尸检时，甲状腺很小，滤泡大小不一，几乎没有或没有胶体。腺垂体含有许多细胞质明显空泡化的细胞。提示临床病理模式是原发性甲状腺异常的结果。可能的机制包括原发性甲状腺发育不全或对促甲状腺激素无反应。
