Roszkiewicz A, Roszkiewicz J, Zawistowski S
Gegenbaurs Morphol Jahrb. 1979;125(3):365-75.
Under short duration hypercalcemia induced by pharmacological doses of vitamin D3 significant ultrastructural changes were observed in the renomedullary interstitial cells of rats. The most striking alteration was the degranulation of these cells accompanied with the increase in volume of the rough and smooth-surfaced endoplasmic reticulum, enlargement of the Golgi apparatus and occurence of osmiophilic inclusions probably of lipid nature in mitochondria. The ultrastructural changes can be regarded as an expression of the increase of a synthetic and secretory activity of the renomedullary interstitial cells and they may be associated with an enhanced production of prostaglandins or other lipid hormonal substances than prostaglandins under condition of hypercalcemia.
在药理学剂量的维生素D3诱导的短期高钙血症情况下，观察到大鼠肾髓质间质细胞有明显的超微结构变化。最显著的改变是这些细胞的脱颗粒，同时伴有粗面和滑面内质网体积增加、高尔基体增大以及线粒体中出现可能为脂质性质的嗜锇性包涵体。超微结构变化可被视为肾髓质间质细胞合成和分泌活性增加的一种表现，并且它们可能与高钙血症条件下前列腺素或其他非前列腺素脂质激素物质的产生增加有关。
