Roszkiewicz A, Roszkiewicz J, Zawistowski S
Gegenbaurs Morphol Jahrb. 1982;128(5):702-11.
The administration of the prostaglandin synthetase inhibitor indomethacin to the rat result in a significant increase of the number as well as the size and density of the lipid granules of renomedullary interstitial cells. The increased granularity is associated with the ultrastructural alterations of the organelles which are characteristic for cells with small secretory activity (a sparse rough and smooth endoplasmic reticulum and a small GOLGI complex). The findings indicate that there exists an inverse correlation between the number of the lipid granules of the interstitial cells and the secretory activity of these cells and seem to support the hypothesis that the interstitial cell lipid granules serve as storage site for renal prostaglandin precursors.
给大鼠施用前列腺素合成酶抑制剂吲哚美辛会导致肾髓质间质细胞脂质颗粒的数量、大小和密度显著增加。颗粒度增加与细胞器的超微结构改变有关，这些改变是分泌活性小的细胞（粗糙和光滑内质网稀疏以及高尔基体复合体小）的特征。这些发现表明，间质细胞脂质颗粒的数量与这些细胞的分泌活性之间存在负相关，似乎支持了间质细胞脂质颗粒作为肾前列腺素前体储存部位的假说。
