Bost Wolfgang, Lemor Robert, Fournelle Marc
Fraunhofer Institut für Biomedizinische Technik (IBMT), Ensheimer Strasse 48, Sankt Ingbert D-66386, Germany.
Appl Opt. 2012 Nov 20;51(33):8041-6. doi: 10.1364/AO.51.008041.
Optoacoustic imaging represents a new modality that allows noninvasive in vivo molecular imaging with optical contrast and acoustical resolution. Whereas structural or functional imaging applications such as imaging of vasculature do not require contrast enhancing agents, nanoprobes with defined biochemical binding behavior are needed for molecular imaging tasks. Since the contrast of this modality is based on the local optical absorption coefficient, all particle or molecule types that show significant absorption cross sections in the spectral range of the laser wavelength used for signal generation are suitable contrast agents. Currently, several particle types such as gold nanospheres, nanoshells, nanorods, or polymer particles are used as optoacoustic contrast agents. These particles have specific advantages with respect to their absorption properties, or in terms of biologically relevant features (biodegradability, binding to molecular markers). In the present study, a comparative analysis of the signal generation efficiency of gold nanorods, polymeric particles, and magnetite particles using a 1064 nm Nd:YAG laser for signal generation is described.
光声成像代表了一种新的成像方式，它能够实现具有光学对比度和声学分辨率的非侵入性体内分子成像。诸如血管成像等结构或功能成像应用不需要造影剂，而分子成像任务则需要具有明确生化结合行为的纳米探针。由于这种成像方式的对比度基于局部光学吸收系数，因此在用于产生信号的激光波长光谱范围内具有显著吸收截面的所有粒子或分子类型都适合作为造影剂。目前，几种粒子类型，如金纳米球、纳米壳、纳米棒或聚合物粒子，被用作光声造影剂。这些粒子在吸收特性方面或在生物学相关特征（生物可降解性、与分子标记物的结合）方面具有特定优势。在本研究中，描述了使用1064nm Nd:YAG激光产生信号对金纳米棒、聚合物粒子和磁铁矿粒子的信号产生效率进行的比较分析。
