Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Cancer Res. 2015 Apr 15;75(8):1548-59. doi: 10.1158/0008-5472.CAN-14-2522. Epub 2015 Apr 2.
Optoacoustic imaging combines the rich contrast of optical methods with the resolution of ultrasound imaging. It can therefore deliver optical visualization of cancer far deeper in tissue than optical microscopy and other conventional optical imaging methods. Technological progress and novel contrast media have resulted in optoacoustic imaging being propagated to basic cancer research and in clinical translation projects. We briefly review recent technological advances, showcase the ability to resolve unique cancer biomarkers based on spectral features at different imaging scales, and highlight the imaging performance achieved in preclinical and clinical imaging applications. .
光声成像是将光学方法的丰富对比度与超声成像的分辨率相结合。因此，它可以提供比光学显微镜和其他传统光学成像方法更深的组织内癌症的光学可视化。技术进步和新型对比剂使光声成像得以在基础癌症研究和临床转化项目中得到推广。我们简要回顾了最近的技术进展，展示了基于不同成像尺度的光谱特征来解析独特癌症生物标志物的能力，并强调了在临床前和临床成像应用中实现的成像性能。
