Flickinger J C, Steiner L
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pennsylvania.
Radiother Oncol. 1990 Mar;17(3):229-37. doi: 10.1016/0167-8140(90)90207-d.
The double logistic product formula is proposed as a method for predicting the probability of developing brain necrosis after high dose irradiation of small target volumes as used in stereotactic radiosurgery. Dose-response data observed for the production of localized radiation necrosis for treating intractable pain with the original Leksell gamma unit were used to choose the best fitting parameters for the double logistic product formula. This model can be used with either exponential or linear quadratic formulas to account for the effects of dose, fractionation and time in addition to volume. Dose-response predictions for stereotactic radiosurgery with different sized collimators are presented.
双逻辑乘积公式被提出作为一种预测在立体定向放射治疗中对小靶体积进行高剂量照射后发生脑坏死概率的方法。使用最初的Leksell伽马刀治疗顽固性疼痛时观察到的局部放射性坏死产生的剂量反应数据，用于选择双逻辑乘积公式的最佳拟合参数。该模型除了可用于考虑体积外，还可与指数公式或线性二次公式一起用于解释剂量、分次照射和时间的影响。文中给出了使用不同尺寸准直器进行立体定向放射治疗的剂量反应预测。
