Flickinger J C
Department of Radiation Oncology, University of Pittsburgh School of Medicine, PA.
Int J Radiat Oncol Biol Phys. 1989 Oct;17(4):879-85. doi: 10.1016/0360-3016(89)90082-5.
An integrated logistic model for predicting the probability of complications when small volumes of tissue receive an inhomogeneous radiation dose is described. This model can be used with either an exponential or linear quadratic correction for dose per fraction and time. Both the exponential and linear quadratic versions of this integrated logistic formula provide reasonable estimates of the tolerance of brain to radiosurgical dose distributions where there are small volumes of brain receiving high radiation doses and larger volumes receiving lower doses. This makes it possible to predict the probability of complications from stereotactic radiosurgery, as well as combinations of fractionated large volume irradiation with a radiosurgical boost. Complication probabilities predicted for single fraction radiosurgery with the Leksell Gamma Unit using 4, 8, 14, and 18 mm diameter collimators as well as for whole brain irradiation combined with a radiosurgical boost are presented. The exponential and linear quadratic versions of the integrated logistic formula provide useful methods of calculating the probability of complications from radiosurgical treatment.
本文描述了一种综合逻辑模型，用于预测小体积组织接受非均匀辐射剂量时发生并发症的概率。该模型可用于对分次剂量和时间进行指数或线性二次校正。这种综合逻辑公式的指数和线性二次版本，对于脑对放射外科剂量分布的耐受性，都能提供合理的估计，即在小体积脑接受高辐射剂量而大体积脑接受低剂量的情况下。这使得预测立体定向放射外科以及分次大体积照射与放射外科增强联合治疗的并发症概率成为可能。文中给出了使用直径为4、8、14和18毫米准直器的Leksell伽马刀进行单次分割放射外科治疗以及全脑照射联合放射外科增强治疗所预测的并发症概率。综合逻辑公式的指数和线性二次版本为计算放射外科治疗并发症概率提供了有用的方法。
