Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Int J Cardiol. 2011 Aug 4;150(3):247-52. doi: 10.1016/j.ijcard.2010.04.011. Epub 2010 May 1.
Recent studies suggest that central obesity is an important predictor of cardiovascular disease (CVD) in addition to overall obesity. Both inflammation and endothelial dysfunction are associated with increased risk of CVD. We examined the association between body mass index (BMI) and waist circumference (WC) with plasma concentrations of biomarkers of inflammation and endothelial dysfunction.
We conducted a cross-sectional study of 2589 lean, moderately active participants aged 20 years and older in Inner Mongolia, China. Overnight fasting blood samples were obtained to measure the biomarkers including C-reactive protein (CRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), and angiotensin II. Height, body weight, and WC were measured by trained staff and BMI was calculated (kg/m(2)).
In univariate analysis, CRP, sICAM-1, and sE-selectin were all significantly higher among individuals with a higher BMI and WC. In multivariate analysis, each standard deviation (SD) increase in WC (9.6 cm) was associated with about 46% higher risk (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.21-1.76) of elevated CRP but a 1 SD increase in BMI (3.5 kg/m(2)) was not associated with the risk of elevated CRP (OR 0.96, 95% CI 0.80-1.16). However, each SD increase in BMI was associated with about 30% higher risk of having elevated E-selectin (OR 1.30, 95% CI 1.08-1.55).
WC is a stronger predictor of inflammation while BMI is a stronger predictor for endothelial dysfunction. These results suggest measuring both BMI and WC will help to assess the risk of CVD in the Chinese population.
最近的研究表明，中心性肥胖除了整体肥胖外，也是心血管疾病（CVD）的重要预测因素。炎症和内皮功能障碍都与 CVD 风险增加有关。我们研究了体重指数（BMI）和腰围（WC）与炎症和内皮功能障碍生物标志物的血浆浓度之间的关系。
我们在中国内蒙古对 2589 名年龄在 20 岁及以上、偏瘦、活动适度的参与者进行了一项横断面研究。采集过夜空腹血样以测量生物标志物，包括 C 反应蛋白（CRP）、可溶性细胞间黏附分子-1（sICAM-1）、可溶性 E-选择素（sE-selectin）和血管紧张素 II。身高、体重和 WC 由经过培训的工作人员测量，BMI 通过计算得出（kg/m²）。
在单变量分析中，BMI 和 WC 较高的个体 CRP、sICAM-1 和 sE-selectin 均显著升高。在多变量分析中，WC 每增加一个标准差（9.6cm），CRP 升高的风险约增加 46%（比值比[OR]1.46，95%置信区间[CI]1.21-1.76），而 BMI 增加一个标准差（3.5kg/m²）与 CRP 升高的风险无关（OR 0.96，95% CI 0.80-1.16）。然而，BMI 每增加一个标准差，E-选择素升高的风险约增加 30%（OR 1.30，95% CI 1.08-1.55）。
WC 是炎症的更强预测因子，而 BMI 是内皮功能障碍的更强预测因子。这些结果表明，测量 BMI 和 WC 将有助于评估中国人群 CVD 的风险。
