Department of Clinical Medicine, Section of Psychiatry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Epidemiology. 2013 Jan;24(1):129-34. doi: 10.1097/EDE.0b013e31827623d0.
Diabetes is associated with an increased risk of several other chronic diseases. In contrast, a previous study found an inverse relation between diabetes and migraine, whereas another large population-based study showed that the prevalence of migraine among patients with diabetes varied strongly depending on age. We aimed to investigate how the prevalence of medically treated migraine in patients with diabetes varied depending on diabetic drug treatment, sex, and age in the complete Norwegian population.
Data on all persons in Norway being prescribed medication for diabetes (n =124,649) or migraine (n = 81,225) in 2006 were obtained from the National Register of Prescriptions and analyzed in a cross-sectional design.
Persons using diabetic drugs had an overall reduced prevalence of medically treated migraine when compared with the nondiabetic population (odds ratio [OR] = 0.72 [95% confidence interval = 0.68-0.75]). The OR was strongly associated with age. Although young persons receiving oral diabetic medication had, in fact, an increased prevalence of medically treated migraine, the prevalence declined with increasing age to about the same reduced prevalence (OR = 0.4-0.6) for all types of diabetes treatment in patients 60 to 69 years of age. The prevalence was equally decreased between men and women.
The results suggest a markedly reduced prevalence of migraine among older patients with diabetes, when compared with the general population. One may speculate that the seemingly protective effect of diabetes on migraine could be a result of neuropathy.
糖尿病与多种其他慢性疾病的风险增加有关。相比之下，先前的一项研究发现糖尿病与偏头痛之间存在反比关系，而另一项大型基于人群的研究表明，糖尿病患者偏头痛的患病率强烈取决于年龄。我们旨在研究在挪威全部人群中，糖尿病患者经医学治疗的偏头痛患病率如何取决于糖尿病药物治疗、性别和年龄。
2006 年，从国家处方登记处获得了所有在挪威接受糖尿病（n=124649）或偏头痛（n=81225）药物治疗的人群的数据，并进行了横断面设计分析。
与非糖尿病患者相比，使用糖尿病药物的患者总体上偏头痛的经医学治疗的患病率降低（比值比[OR] = 0.72 [95%置信区间 = 0.68-0.75]）。OR 与年龄强烈相关。尽管接受口服糖尿病药物治疗的年轻人实际上偏头痛的经医学治疗的患病率增加，但患病率随着年龄的增长而下降，到 60-69 岁时，所有类型的糖尿病治疗的患病率均降低到相同的低水平（OR = 0.4-0.6）。男女之间的患病率同样降低。
与一般人群相比，这些结果表明年龄较大的糖尿病患者偏头痛的患病率明显降低。人们可能推测，糖尿病对偏头痛的这种看似保护作用可能是神经病的结果。
