Firdaus Muhammad, Gill Arwinder S, Andriani Rini, Cahyanti Dian, Yunti Maria R, Faried Ahmad
Department of Neurosurgery, Dharmais National Cancer Hospital, West Jakarta, Indonesia.
Department of Neurology, Dharmais National Cancer Hospital, West Jakarta, Indonesia.
Surg Neurol Int. 2020 Nov 18;11:391. doi: 10.25259/SNI_370_2020. eCollection 2020.
Meningiomas are common central nervous system neoplasms, accounts for 30% of all primary intracranial neoplasms; the occurrence of meningiomas with cystic lesions is an exceptionally rare. Lymphoplasmacyte-rich meningioma (LPRM) is a rare pathological entity belong to the World Health Organization Grade I meningiomas. LPRM is characterized by abundant lymphoplasmacytic infiltrates which over-shadow the underlying meningothelial component.
A 42-year-old male was admitted to our hospital with a chronic headache for about 3 weeks prior to admission. His symptoms worsen, and subsequently, he experienced left extremities weakness about 1 week before admission. His brain magnetic resonance imaging revealed an irregular and heterogeneously enhancing solid lesion with intratumoral cystic changes at the temporal lobe. A gross total resection was performed; pathological examination revealed a cystic LPRM.
This rare variant of meningioma is a benign tumor entity featured with massive inflammatory cell infiltration and often less proportion of meningothelial elements. Surgical resection remains the treatment of choice. This is the first report regarding cystic LPRM from Indonesia; we also summarized relevant literature upto-date, May 2020, reported LPRM cases.
脑膜瘤是常见的中枢神经系统肿瘤，占所有原发性颅内肿瘤的30%；伴有囊性病变的脑膜瘤极为罕见。富含淋巴细胞和浆细胞的脑膜瘤（LPRM）是一种罕见的病理实体，属于世界卫生组织I级脑膜瘤。LPRM的特征是大量淋巴细胞和浆细胞浸润，掩盖了潜在的脑膜上皮成分。
一名42岁男性因入院前约3周的慢性头痛入院。入院前约1周，他的症状加重，随后出现左侧肢体无力。他的脑部磁共振成像显示颞叶有一个不规则的、不均匀强化的实性病变，伴有瘤内囊性改变。进行了全切除；病理检查显示为囊性LPRM。
这种罕见的脑膜瘤变体是一种良性肿瘤实体，其特征是大量炎性细胞浸润，脑膜上皮成分比例通常较低。手术切除仍然是首选治疗方法。这是来自印度尼西亚的关于囊性LPRM的首例报告；我们还总结了截至2020年5月的相关文献报道的LPRM病例。
