基于一项荟萃分析，XRCC1基因Arg399Gln多态性与胃癌之间不存在关联。

Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis.

作者信息

Liu B M, Liu T M, You B S, You H Y, Yang J, Li L, He Y C

机构信息

Department of Anatomy, Harbin Medical University, Harbin, China.

出版信息

Genet Mol Res. 2012 Nov 12;11(4):3852-60. doi: 10.4238/2012.November.12.2.

DOI:10.4238/2012.November.12.2

PMID:23212324

Abstract

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a significant association between the XRCC1 Arg399Gln polymorphism and gastric cancer risk (in the additive inheritance model, OR = 0.986, 95%CI = 0.831-1.156, in the dominant inheritance model, OR = 1.044, 95%CI = 0.890-1.224 and in the recessive inheritance model, OR = 0.975, 95%CI = 0.894-1.063). We conclude that the XRCC1 Arg399Gln polymorphism is not a risk factor for developing gastric cancer.

摘要

已对XRCC1基因第399位密码子精氨酸突变为谷氨酰胺（Arg399Gln）的多态性与胃癌易感性之间的关联进行了研究；总体而言，结果尚无定论。我们对13项病例对照研究进行了荟萃分析，其中包括3278例病例和6243例对照。采用粗比值比（OR）及95%置信区间（95%CI）来评估这种可能的关联。我们没有发现证据表明XRCC1基因Arg399Gln多态性与胃癌风险之间存在显著关联（在加性遗传模型中，OR = 0.986，95%CI = 0.831 - 1.156；在显性遗传模型中，OR = 1.044，95%CI = 0.890 - 1.224；在隐性遗传模型中，OR = 0.975，95%CI = 0.894 - 1.063）。我们得出结论，XRCC1基因Arg399Gln多态性不是胃癌发生的危险因素。