Dong L M, Zhang X Y, Teng H, Li M S, Wang P
Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Department of Neurosurgery, The Shengjing Affiliated Hospital of China Medical University, Shenyang, China.
Genet Mol Res. 2014 Nov 28;13(4):9976-85. doi: 10.4238/2014.November.28.2.
We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies showed no significant association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in comparisons of the glutamine (Gln) allele vs arginine (Arg) allele, Arg/Arg vs (Gln/Gln + Gln/Arg), Gln/Gln vs (Gln/Arg + Arg/Arg), Gln/Gln vs Arg/Arg, and Gln/Arg vs Arg/Arg [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.80-1.16, P = 0.70; OR = 1.13, 95%CI = 0.70-1.82, P = 0.62; OR = 0.92, 95%CI = 0.79-1.07, P = 0.29; OR = 0.90, 95%CI = 0.69-1.16, P = 0.42; OR = 0.89, 95%CI = 0.75-1.05, P = 0.17, respectively]. In subgroup analysis by ethnicity, no association was observed between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in Caucasian, Mongoloid, or black populations. We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk.
我们通过进行一项荟萃分析，研究了X射线修复交叉互补基因1（XRCC1）的Arg399Gln多态性是否为膀胱癌的一个风险因素。我们在PubMed和Embase数据库中检索研究。这项荟萃分析纳入了16项病例对照研究，包括892例前列腺癌病例和1020例健康对照。基于这些研究的荟萃分析结果显示，在谷氨酰胺（Gln）等位基因与精氨酸（Arg）等位基因、Arg/Arg与（Gln/Gln + Gln/Arg）、Gln/Gln与（Gln/Arg + Arg/Arg）、Gln/Gln与Arg/Arg以及Gln/Arg与Arg/Arg的比较中，XRCC1 Arg399Gln多态性与膀胱癌风险之间无显著关联[比值比（OR）= 0.96，95%置信区间（CI）= 0.80 - 1.16，P = 0.70；OR = 1.13，95%CI = 0.70 - 1.82，P = 0.62；OR = 0.92，95%CI = 0.79 - 1.07，P = 0.29；OR = 0.90，95%CI = 0.69 - 1.16，P = 0.42；OR = 0.89，95%CI = 0.75 - 1.05，P = 0.17]。在按种族进行的亚组分析中，在白种人、蒙古人种或黑人人群中，未观察到XRCC1 Arg399Gln多态性与膀胱癌风险之间存在关联。我们未发现XRCC1 Arg399Gln多态性与膀胱癌风险之间存在关联。
