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母体母乳和婴儿尿液中的双酚 A 浓度。

Bisphenol A concentrations in maternal breast milk and infant urine.

机构信息

Nursing Programs, School of Nursing and Health Sciences, Simmons College, 300 The Fenway, Science Building, Room 314, Boston, MA, 02115, USA.

出版信息

Int Arch Occup Environ Health. 2014 Jan;87(1):13-20. doi: 10.1007/s00420-012-0834-9. Epub 2012 Dec 5.

Abstract

PURPOSE

The present report describes the distribution of breast milk and urinary free and total bisphenol A (BPA) concentrations, from 27 postpartum women and their 31 infants, and explores the influence of age, sex, and nutritional source on infant BPA urinary concentration.

METHODS

Both free (unconjugated) and total (free plus conjugated) BPA concentrations from women's breast milk samples and infants' urine samples were measured by online solid-phase extraction coupled to high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Descriptive statistics and nonparametric tests of group comparisons were conducted.

RESULTS

Total BPA was detected in 93 % of urine samples in this healthy infant population aged 3-15 months who were without known environmental exposure to BPA [interquartile range (IQR) = 1.2-4.4 μg/L)]. Similarly, 75 % of the mothers' breast milk samples had detectable concentrations of total BPA (IQR = 0.4-1.4 μg/L). The magnitude and frequency of detection of free BPA in the children's urine and the mothers' breast milk were much lower than the total concentrations.

CONCLUSIONS

Total BPA was detected in 93 % of this healthy infant population aged 3-15 months who are without known environmental exposure to BPA. Neither free nor total BPA urinary concentrations differed significantly by infant's sex or by nutritional source (breast milk and/or formula) while age group was of borderline significance. There were no significant correlations between free or total BPA concentrations in mothers' breast milk and their infants' urine.

摘要

目的

本报告描述了 27 位产后妇女及其 31 名婴儿的母乳和尿液中游离和总双酚 A(BPA)浓度的分布,并探讨了婴儿 BPA 尿浓度受年龄、性别和营养来源影响的情况。

方法

通过在线固相萃取与高效液相色谱-同位素稀释串联质谱联用,测定了妇女母乳样本和婴儿尿液样本中游离(未结合)和总(游离加结合)BPA 的浓度。进行了描述性统计和组间比较的非参数检验。

结果

在这个无已知环境 BPA 暴露的 3-15 月龄健康婴儿人群中,93%的尿液样本中检测到总 BPA[四分位间距(IQR)=1.2-4.4μg/L]。同样,75%的母亲母乳样本中检测到总 BPA 的浓度(IQR=0.4-1.4μg/L)。儿童尿液和母亲母乳中游离 BPA 的检测量和检测频率均远低于总浓度。

结论

在这个无已知环境 BPA 暴露的 3-15 月龄健康婴儿人群中,93%的婴儿尿液中检测到总 BPA。婴儿的性别或营养来源(母乳和/或配方奶)均未显著影响游离或总 BPA 尿浓度,而年龄组则具有边界显著性。母亲母乳和婴儿尿液中的游离或总 BPA 浓度之间无显著相关性。

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