İzmir Democracy University Faculty of Health Sciences, Department of Nutrition and Dietetics, İzmir, Turkey
Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey
J Clin Res Pediatr Endocrinol. 2021 Nov 25;13(4):375-383. doi: 10.4274/jcrpe.galenos.2020.2021.0305. Epub 2021 Mar 22.
Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 μg/kg body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and thus exclusively breastfed infants’ exposure to BPA.
Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants’ demographic characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire.
Eighty women participated. Median milk free BPA level was 0.63 μg/L. There was no statistically significant association between maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless, there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and p=0.018, respectively). Exclusively breastfed infants’ mean BPA exposure was 0.0099±0.0079 μg/kg bw/day. There was a moderate negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003).
BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants in this cohort was safe.
双酚 A（BPA）是一种已知的内分泌干扰物，游离的 BPA 会与雌激素相互作用。BPA 还具有脂溶性，因此会污染母乳。欧洲食品安全局设定了哺乳期婴儿临时耐受每日摄入量的限值为 4μg/kg 体重/天。本研究的目的是测量土耳其妇女母乳中的 BPA 浓度，从而了解纯母乳喂养婴儿接触 BPA 的情况。
招募健康的产后、纯母乳喂养的妇女，并采集母乳样本。使用竞争性酶联免疫吸附测定法分析牛奶样本中的游离 BPA 浓度。通过详细的问卷，面对面访谈调查参与者的人口统计学特征和营养习惯。
共有 80 名妇女参与了研究。母乳中游离 BPA 的中位数水平为 0.63μg/L。母乳中游离 BPA 浓度与母亲的体重指数、分娩类型、产次、婴儿出生周、婴儿出生体重均无统计学显著关联。然而，母乳 BPA 水平与快餐和碳酸饮料的消费呈显著正相关（p=0.022 和 p=0.018）。纯母乳喂养婴儿的平均 BPA 暴露量为 0.0099±0.0079μg/kg bw/day。婴儿 BPA 暴露量与婴儿当前体重呈中度负相关（r=0.327，p=0.003）。
纯母乳喂养婴儿的 BPA 暴露量处于可接受的范围内，该队列婴儿目前的饮食暴露水平是安全的。
