Emmadi Rajyasree, Wiley Elizabeth L
Department of Pathology, University of Illinois Hospital and Health Sciences System, 840 South Wood Street, M/C 847, Chicago, IL 60612, USA.
Int J Surg Oncol. 2012;2012:180259. doi: 10.1155/2012/180259. Epub 2012 Nov 19.
Tumor surgical resection margin status is important for any malignant lesion. When this occurs in conjunction with efforts to preserve or conserve the afflicted organ, these margins become extremely important. With the demonstration of no difference in overall survival between mastectomy versus lumpectomy and radiation for breast carcinoma, there is a definite trend toward smaller resections combined with radiation, constituting "breast-conserving therapy." Tumor-free margins are therefore key to the success of this treatment protocol. We discuss the various aspects of margin status in this setting, from a pathology perspective, incorporating the past and current practices with a brief glimpse of emerging future techniques.
肿瘤手术切缘状态对于任何恶性病变都很重要。当这与保留或保全患病器官的努力同时出现时，这些切缘就变得极其重要。鉴于乳房切除术与乳房肿瘤切除术加放疗在乳腺癌总体生存率方面并无差异的证明，目前存在一种明确的趋势，即倾向于采用更小的切除术并结合放疗，即“保乳治疗”。因此，无瘤切缘是该治疗方案成功的关键。我们从病理学角度讨论这种情况下切缘状态的各个方面，纳入过去和当前的实践，并简要展望新兴的未来技术。
