Abiodun Moses Temidayo, Iduoriyekemwen Nosakhare J, Abiodun Phillip O
Department of Child Health, University of Benin Teaching Hospital, Benin 300001, Nigeria.
Int J Nephrol. 2012;2012:861296. doi: 10.1155/2012/861296. Epub 2012 Nov 19.
Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent. Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children. Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P = 0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m(2), significantly lower than 126.9 ± 28.5 mL/min/1.73 m(2) in the control group, (P = 0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m(2) (21.5% versus 5.4%; P = 0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r = 0.23; P = 0.022). Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method.
背景。人类免疫缺陷病毒（HIV）现已被确认为肾脏疾病的一个风险因素，在非洲裔人群中负担加重。方法。我们采用酶联免疫吸附测定（ELISA）技术测量了205名未接受抗逆转录病毒治疗（ART）的HIV感染儿童的血清胱抑素C水平，并将其与明显健康儿童的水平进行比较。结果。HIV感染儿童的血清胱抑素C平均水平±标准差为1.01±0.44mg/L，显著高于对照组的平均值，即0.72±0.20mg/L（P = 0.000）。HIV感染儿童基于胱抑素C的估计肾小球滤过率（GFR）平均水平±标准差为102.7±31.0mL/min/1.73m²，显著低于对照组的126.9±28.5mL/min/1.73m²（P = 0.014）。与对照组相比，HIV感染儿童中估算肾小球滤过率（eGFR）<90mL/min/1.73m²的比例显著更高（21.5%对5.4%；P = 0.00）。HIV感染儿童中慢性肾脏病（CKD）的患病率为10.7%。≥5岁的HIV感染儿童基于胱抑素C的eGFR与他们的CD4细胞计数呈正相关（r = 0.23；P = 0.022）。结论。HIV感染儿童中CKD的患病率很高，需要使用基于胱抑素C的方法定期监测他们的肾功能。
