Gong Ting, Wang Jiadong
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Aug;26(16):763-6.
The purpose of this review is to investigate the value of the calcification in differentiating malignant thyroid neoplasm and the molecular mechanisms for the formation of the calcification. Many published reports have proved the presence of calcifications in thyroid neoplasm and calcified nodules in these studies are more frequently malignant than noncalcified nodules. Through viewing the related references, we found that psammoma bodies (PBs), Runx2, osteocalcin, osteopontin, CD44v6 play an important role in the molecular mechanisms in the formation of the calcification in PTC. But further study is required for elucidating the mode of action.
本综述的目的是探讨钙化在鉴别甲状腺恶性肿瘤中的价值以及钙化形成的分子机制。许多已发表的报告证实甲状腺肿瘤中存在钙化，并且在这些研究中，钙化结节比非钙化结节更常为恶性。通过查阅相关参考文献，我们发现砂粒体（PBs）、Runx2、骨钙素、骨桥蛋白、CD44v6在甲状腺乳头状癌（PTC）钙化形成的分子机制中起重要作用。但仍需要进一步研究以阐明其作用方式。
