[甲状腺乳头状癌侵袭与埃兹蛋白和E-钙黏蛋白相关性的研究]

[The study of the correlation of papillary thyroid carcinoma's invasion toward Ezrin and E-cadherin].

作者信息

Liu Chang, Chen Xi, Gao Zhengnan, Liu Zhong, Tao Xiaofeng

机构信息

Department of Endocrinology, Dalian Central Hospital, Dalian, 116033, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(17):789-91, 795.

PMID:23214316

Abstract

OBJECTIVE

In order to assess the significance of Ezrin and E-Cadherin in invasion and metastasis of papillary thyroid carcinoma (PTC).

METHOD

The 81 paraffin-embedded specimen PTC and normal thyroid tissues adjacent to cancer operated from 2005 to 2008 were tested. The expressions of Ezrin, E-Cadherin in the specimen were assayed by immunohistochemical staining. The correlation between the 2 factors (Ezrin, E-Cadherin) and clinical features of PTC such as gender, age, tumor size, invasion, lymph node metastasis, and TNM stage were studied.

RESULTS

The rates of immuno-positive staining Ezrin in PTC was higher than the normal thyroid tissues adjacent to cancer with significant difference respectively (chi2 = 61.691, P < 0.01). The rates of immuno-positive staining E-Cadherin in PTC was lower than the normal thyroid tissues adjacent to cancer with significant difference respectively (chi2 = 64.241, P < 0.01). The expressions of Ezrin and E-cadherin were related to age, invasion, lymph node metastasis, and TNM. There was correlation between the expressions of Ezrin and E-Cadherin in PTC (r = -0.471, P < 0.01).

CONCLUSION

The high expressions of Ezrin and the low expression of E-Cadherin were related to invasion and metastasis in PTC. Between the 2 factors has cooperative. Combined detection of the expression of Ezrin and E-Cadherin in PTC might served as invasion, metastasis and important prognostic predictors.

摘要

目的

评估埃兹蛋白（Ezrin）和E-钙黏蛋白（E-Cadherin）在甲状腺乳头状癌（PTC）侵袭和转移中的意义。

方法

检测2005年至2008年手术切除的81例PTC石蜡包埋标本及癌旁正常甲状腺组织。采用免疫组织化学染色法检测标本中Ezrin、E-Cadherin的表达。研究这两个因素（Ezrin、E-Cadherin）与PTC的性别、年龄、肿瘤大小、侵袭、淋巴结转移及TNM分期等临床特征之间的相关性。

结果

PTC中Ezrin免疫阳性染色率高于癌旁正常甲状腺组织，差异有统计学意义（χ2 = 61.691，P < 0.01）。PTC中E-Cadherin免疫阳性染色率低于癌旁正常甲状腺组织，差异有统计学意义（χ2 = 64.241，P < 0.01）。Ezrin和E-钙黏蛋白的表达与年龄、侵袭、淋巴结转移及TNM分期有关。PTC中Ezrin与E-Cadherin的表达之间存在相关性（r = -0.471，P < 0.01）。