Department of Experimental Cardiology, University Medical Centre Utrecht, 3584 CX, Utrecht, The Netherlands.
Eur J Clin Invest. 2013 Feb;43(2):113-20. doi: 10.1111/eci.12022. Epub 2012 Dec 6.
Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we studied the effect of cardiovascular interventions and clinical characteristics on plasma sST2 expression levels.
In the current study, sST2 levels were assessed in the plasma of patients scheduled for coronary artery bypass grafting (CABG) (n = 76), percutaneous coronary intervention (PCI) (n = 68) or peripheral vascular surgery (n = 27).
Age was the only classical risk factor significantly correlating with sST2 levels. Soluble ST2 levels were significantly increased 1 h after CABG (48 [33-70] vs. 61 [42-89] pg/mL, P = 0·001) and increased even further after 24 h (1116 [578-13 666] pg/mL, P < 0·001). An average threefold increase in sST2 levels was also observed in patients 24 h after peripheral interventions (30 [21-41] vs. 98 [48-211] pg/mL, P < 0·001). Two months after PCI, we found that sST2 levels were significantly higher compared with baseline levels (41 [29-61] vs. 48 [31-80] pg/mL, P = 0·007, n = 52). In addition, we did not observe an association between sST2 and any inflammatory or cardiac-specific markers that were measured in this study.
Soluble ST2 increases significantly following cardiovascular interventions. The notion of a recent cardiovascular intervention is a strong determinant of sST2 levels and therefore needs to be taken into account when exploring sST2 as predictor of future cardiovascular events.
可溶性 ST2（sST2）是白细胞介素-1 受体家族的成员，被提出作为一种新的生物标志物，具有预测心血管疾病患者心力衰竭和死亡率的价值。临床特征对 sST2 水平变异性的影响相对未知。在这里，我们研究了心血管干预和临床特征对血浆 sST2 表达水平的影响。
在本研究中，评估了 76 例行冠状动脉旁路移植术（CABG）、68 例行经皮冠状动脉介入治疗（PCI）和 27 例行外周血管手术的患者的血浆 sST2 水平。
年龄是唯一与 sST2 水平显著相关的经典危险因素。CABG 后 1 小时 sST2 水平显著升高（48[33-70] vs. 61[42-89]pg/ml，P=0.001），24 小时后进一步升高（1116[578-13666]pg/ml，P<0.001）。外周介入后 24 小时 sST2 水平也平均升高三倍（30[21-41] vs. 98[48-211]pg/ml，P<0.001）。PCI 后 2 个月，我们发现 sST2 水平与基线水平相比显著升高（41[29-61] vs. 48[31-80]pg/ml，P=0.007，n=52）。此外，我们没有观察到 sST2 与本研究中测量的任何炎症或心脏特异性标志物之间存在关联。
心血管干预后 sST2 显著增加。最近的心血管干预是 sST2 水平的一个重要决定因素，因此在探索 sST2 作为未来心血管事件的预测指标时需要考虑这一点。
