Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA.
Cell Metab. 2012 Dec 5;16(6):691-2. doi: 10.1016/j.cmet.2012.11.009.
Type 2 diabetes is characterized by insulin resistance, and the hyperinsulinemia commonly observed in patients is thought to be a compensatory response. Yet it has been difficult to disentangle cause and effect. Mehran et al. (2012) provide genetic evidence that a reduction of insulin secretion prevents high-fat feeding-induced obesity.
2 型糖尿病的特征是胰岛素抵抗，而患者中常见的高胰岛素血症被认为是一种代偿性反应。然而，要理清因果关系一直很困难。Mehran 等人（2012 年）提供了遗传证据，表明胰岛素分泌减少可预防高脂肪喂养引起的肥胖。
