García-Berrocal J R, De Diego B, Roldán-Fidalgo A, Yebra-Bango M, Millán I, Trinidad A, Ramírez-Camacho R
Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
J Laryngol Otol. 2013 Jan;127(1):38-42. doi: 10.1017/S0022215112002769. Epub 2012 Dec 7.
To evaluate patients with systemic lupus erythematosus and normal hearing over 10 years, compared with healthy controls.
Thirty patients diagnosed with systemic lupus erythematosus were evaluated in a prospective, descriptive study. Eight patients fulfilled the inclusion criteria, i.e. normal otoscopy, normal hearing, normal imaging and disease duration of less than one year. Eleven healthy companions of ENT patients were recruited as controls.
At study commencement, the mean patient age was 32.75 years (range, 15-49 years) and there were no statistically significant audiometric differences between patients and controls. No statistically significant audiometric changes were found either within or between the patient and control groups at 10-year follow up.
These results supply no evidence for progressive hearing loss in systemic lupus erythematosus patients with no hearing involvement at study commencement. Therefore, we recommend audiometric tests only for systemic lupus erythematosus patients complaining of hearing loss, or for other clinical purposes. It is conceivable that asymptomatic hearing loss could be observed over a more extended follow-up period (i.e. more than 10 years).
对系统性红斑狼疮且听力正常的患者进行为期10年的评估,并与健康对照者进行比较。
在一项前瞻性描述性研究中对30例诊断为系统性红斑狼疮的患者进行评估。8例患者符合纳入标准,即耳镜检查正常、听力正常、影像学检查正常且病程少于1年。招募11名耳鼻喉科患者的健康同伴作为对照。
研究开始时,患者的平均年龄为32.75岁(范围15 - 49岁),患者与对照者之间在听力测定方面无统计学显著差异。在10年随访中,患者组和对照组内部及组间均未发现统计学显著的听力测定变化。
这些结果没有为研究开始时无听力受累的系统性红斑狼疮患者出现进行性听力损失提供证据。因此,我们建议仅对主诉听力损失的系统性红斑狼疮患者或出于其他临床目的进行听力测定检查。可以想象,在更长的随访期(即超过10年)可能会观察到无症状性听力损失。