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两种机械方法预防妇科盆腔手术后血栓栓塞:一项前瞻性、随机研究。

Two mechanical methods for thromboembolism prophylaxis after gynaecological pelvic surgery: a prospective, randomised study.

机构信息

Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

出版信息

Chin Med J (Engl). 2012 Dec;125(23):4259-63.

Abstract

BACKGROUND

Venous thromboembolism is known to be an important social and health care problem because of its high incidence among patients who undergo surgery. Studies on the mechanical prophylaxis of thromboembolism after gynaecological pelvic surgery are few. The aim of our study was to evaluate the effect of mechanical thromboembolism prophylaxis after gynaecological pelvic surgery using a combination of graduated compression stockings (GCS) and intermittent pneumatic compression (IPC) or GCS alone.

METHODS

The study was performed on 108 patients who were randomly assigned to two groups. The first group received GCS before the operation and IPC during the operation (IPC + GCS group). The second group received GCS before the operation (GCS group). To analyze the effect of the preventive measures and the laboratory examination on the incidence of thrombosis and to compare the safety of these measures, the incidence of adverse reactions was assessed.

RESULTS

The morbidity associated with DVT was 4.8% (5/104) in the IPC + GCS group and 12.5% (14/112) in the GCS group. There were significant statistical differences between the two groups. There were no adverse effects in either group.

CONCLUSIONS

The therapeutic combination of GCS and IPC was more effective than GCS alone for thrombosis prevention in high-risk patients undergoing gynaecological pelvic surgery, and there were no adverse effects in either group.

摘要

背景

静脉血栓栓塞症是一种重要的社会和医疗保健问题,因为它在接受手术的患者中发病率很高。关于妇科盆腔手术后机械性血栓栓塞预防的研究很少。我们的研究目的是评估使用分级压缩袜(GCS)和间歇性气动压缩(IPC)联合或单独 GCS 对妇科盆腔手术后血栓栓塞的预防效果。

方法

这项研究在 108 名患者中进行,他们被随机分配到两组。第一组在手术前接受 GCS,并在手术期间接受 IPC(IPC+GCS 组)。第二组在手术前接受 GCS(GCS 组)。为了分析预防措施和实验室检查对血栓形成发生率的影响,并比较这些措施的安全性,评估了不良反应的发生率。

结果

IPC+GCS 组的 DVT 发病率为 4.8%(5/104),GCS 组为 12.5%(14/112)。两组之间存在显著的统计学差异。两组均无不良反应。

结论

GCS 和 IPC 的联合治疗在预防妇科盆腔手术高危患者血栓形成方面比单独使用 GCS 更有效,且两组均无不良反应。

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