Humanitas Clinical and Research Center, University of Milan, Via Manzoni 56, 20089 Rozzano, Milano, Italy.
Cell Stem Cell. 2012 Dec 7;11(6):730-2. doi: 10.1016/j.stem.2012.11.016.
Two studies in this issue of Cell Stem Cell highlight context-dependent roles for MSCs in controlling tumor growth. Lee et al. (2012) show that preactivated MSCs have antitumor effects upon adoptive transfer in vivo, and Ren et al. (2012) show that tumor-resident MSCs can promote tumor growth by influencing macrophages.
本期《细胞—干细胞》中的两项研究强调了间充质干细胞在控制肿瘤生长方面的依赖于背景的作用。Lee 等人（2012 年）表明，预激活的间充质干细胞在体内过继转移时有抗肿瘤作用，而 Ren 等人（2012 年）表明，肿瘤驻留的间充质干细胞可以通过影响巨噬细胞促进肿瘤生长。
