TGF-β 在干细胞生物学中的作用。
The harmonies played by TGF-β in stem cell biology.
机构信息
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
出版信息
Cell Stem Cell. 2012 Dec 7;11(6):751-64. doi: 10.1016/j.stem.2012.11.001.
Abstract
To rejuvenate tissues and/or repair wounds, stem cells must receive extrinsic signals from their surrounding environment and integrate them with their intrinsic abilities to self-renew and differentiate to make tissues. Increasing evidence suggests that the superfamily of transforming growth factor-βs (TGF-βs) constitute integral components in the intercellular crosstalk between stem cells and their microenvironment. In this review, we summarize recent advances in our understanding of TGF-β superfamily functions in embryonic and adult stem cells. We discuss how these pathways help to define the physiological environment where stem cells reside, and how perturbations in the signaling circuitry contribute to cancers.
摘要
为了使组织恢复活力和/或修复伤口，干细胞必须从其周围环境中接收外在信号，并将这些信号与其自我更新和分化的内在能力结合起来，以形成组织。越来越多的证据表明，转化生长因子-β（TGF-β）超家族构成了干细胞与其微环境之间细胞间通讯的组成部分。在这篇综述中，我们总结了我们对 TGF-β超家族在胚胎和成人干细胞中的功能的最新认识。我们讨论了这些途径如何帮助定义干细胞所处的生理环境，以及信号转导电路的干扰如何导致癌症。
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