Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892–1156, USA.
Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):246-50. doi: 10.1016/j.pcad.2012.09.002.
In 1959 and 1960 the results of two randomized controlled trials demonstrated that bilateral internal mammary artery ligation was no better than a sham intervention in the treatment of angina. These landmark trials were the first to use blinded placebo controls to evaluate invasive procedures. Revisiting the story of internal mammary artery ligation offers valuable insights into the ethics of sham-controlled trials and the implications of the placebo effect for thinking about risk-benefit assessment of sham procedures.
1959 年和 1960 年，两项随机对照试验的结果表明，双侧内乳动脉结扎术在治疗心绞痛方面并不优于假手术干预。这些具有里程碑意义的试验首次使用盲法安慰剂对照来评估有创性操作。回顾内乳动脉结扎术的历史，可以为假手术对照试验的伦理学以及安慰剂效应对假手术风险效益评估的意义提供有价值的见解。
