Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia School of Medicine, Espinardo Campus, Espinardo, Murcia, 30100, Spain.
Environ Health. 2012 Dec 8;11:90. doi: 10.1186/1476-069X-11-90.
In animals, anogenital distance (AGD) at birth reflects androgen levels during pregnancy and predicts adult AGD. Little is known about AGD in relation to female reproductive characteristics in humans, a question this study was designed to explore.
We used multiple linear and logistic regression analyses to model the relationships between adult female reproductive system characteristics (e.g. ovarian morphology, menstrual cycle) and two measures of AGD [anus-fourchette (AGD(AF)) and anus-clitoris (AGD(AC))] in 100 college-age volunteers in Spain. Ovarian morphology was classified as having < 6 or ≥ 6 follicles per ovary.
Both AGD measures were positively associated with ovarian follicle number, with AGD(AF) being more strongly associated. Women in the upper tertile of the AGD(AF) and AGD(AC) distributions were more likely to have ≥ 6 ovarian follicles [OR: 6.0 (95% CI 2.0, 17.6) and 3.0 (95% CI 1.1, 8.6), respectively] compared to women in the lowest tertile.
Increased follicular recruitment has been related to excess androgen exposure in utero in toxicological studies. Our results suggest that the androgenic environment during early fetal life may influence reproductive system development, including AGD, in human females.
在动物中，出生时的肛门生殖器距离（AGD）反映了怀孕期间的雄激素水平，并预测了成人的 AGD。关于人类女性生殖特征与 AGD 的关系，人们知之甚少，本研究旨在探讨这一问题。
我们使用多元线性和逻辑回归分析来构建成年女性生殖系统特征（如卵巢形态、月经周期）与两种 AGD 测量值[肛门-四叉（AGD(AF)）和肛门-阴蒂（AGD(AC)）]之间的关系模型，共纳入了 100 名西班牙大学生志愿者。卵巢形态分为每侧卵巢 < 6 个或≥ 6 个卵泡。
两种 AGD 测量值均与卵巢卵泡数量呈正相关，且 AGD(AF)的相关性更强。AGD(AF)和 AGD(AC)分布中位于上三分之一的女性更有可能有≥ 6 个卵巢卵泡[比值比（OR）：6.0（95%置信区间 2.0，17.6）和 3.0（95%置信区间 1.1，8.6）]，与位于下三分之一的女性相比。
毒理学研究表明，过多的雄激素暴露与卵泡募集增加有关。我们的研究结果表明，胎儿生命早期的雄激素环境可能会影响女性的生殖系统发育，包括 AGD。
