女性的生育能力和肛殖距。
Fertility and anogenital distance in women.
机构信息
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, Beer-Sheva, Israel.
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Reprod Toxicol. 2017 Oct;73:345-349. doi: 10.1016/j.reprotox.2017.07.009. Epub 2017 Jul 22.
BACKGROUND
Human and animal studies have found an association between prenatal androgen exposure and the anogenital distance (AGD). The aims of this study were to study the association between female AGD, reproductive health and background characteristics.
METHODS
This was a cross sectional study, in which AGD were measured in 300 pregnant women who were recruited early during the first stage of labor. Demographic and health characteristics were collected and studied in association with AGD measurements.
RESULTS
AGD presented with normal distribution (mean 40.3mm±10.7) and was positively associated with maternal age (beta=0.032, 95%CI 0.007-0.05, p=0.01) and negatively associated with infertility treatments (beta=-1.06, 95%CI -1.99 to -0.12, p=0.03). AGD was not associated with parity, ethnicity, height and other characteristics.
CONCLUSIONS
Adult females AGD is associated with age and fertility problems. Adult female AGD, used as a marker of early life exposure to EDCs, is possibly associated with reproductive characteristics.
背景
人类和动物研究发现，产前雄激素暴露与肛门生殖器距离（AGD）之间存在关联。本研究旨在研究女性 AGD 与生殖健康和背景特征之间的关系。
方法
这是一项横断面研究，共招募了 300 名在分娩第一阶段早期的孕妇，测量了她们的 AGD。收集了人口统计学和健康特征，并与 AGD 测量值进行了关联研究。
结果
AGD 呈正态分布（平均值为 40.3mm±10.7），与母亲年龄呈正相关（β=0.032，95%CI 0.007-0.05，p=0.01），与不孕治疗呈负相关（β=-1.06，95%CI -1.99 至-0.12，p=0.03）。AGD 与产次、种族、身高和其他特征无关。
结论
成年女性的 AGD 与年龄和生育问题有关。作为 EDC 暴露早期生命的标志物的成年女性 AGD 可能与生殖特征有关。
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