12型腺病毒缺陷病毒粒子的结构与功能

Mak I, Ezoe H, Mak S

J Virol. 1979 Oct;32(1):240-50. doi: 10.1128/JVI.32.1.240-250.1979.

Purified human adenovirus type 12 preparations contain defective virions with a lighter density. These defective virions were isolated, and their biological functions and DNA were characterized. They can induce early and late antigens in infected cells and tumors in newborn hamsters with similar efficiency as complete virions. The majority of the DNA molecules from light virions contain deletions mapping near 16% from the left-hand end of the genome. Mechanisms for the generation of these molecules are discussed.

纯化的12型人腺病毒制剂含有密度较轻的缺陷病毒粒子。分离出这些缺陷病毒粒子，并对其生物学功能和DNA进行了表征。它们能在感染细胞和新生仓鼠肿瘤中诱导早期和晚期抗原，效率与完整病毒粒子相似。来自轻型病毒粒子的大多数DNA分子含有基因组左端约16%处的缺失。文中讨论了这些分子的产生机制。