回顾性研究血液透析患者血管通路感染相关的微生物。
Retrospective study of microorganisms associated with vascular access infections in hemodialysis patients.
机构信息
Dental Hygiene Program, College of Arts and Sciences, University of New Haven, West Haven, Connecticut, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):56-61. doi: 10.1016/j.oooo.2012.08.445.
OBJECTIVE
The aim of this study was to assess microorganisms associated with vascular access-associated infections (VAIs) in hemodialysis patients, with respect to possible origin from the mouth.
STUDY DESIGN
A retrospective and comparative analysis of the microbes associated with VAI in hemodialysis patients treated during a 10-year period was performed with the Human Oral Microbiome Database (HOMD).
RESULTS
Of 218 patient records identified, 65 patients collectively experienced 115 VAI episodes. The most common microorganisms involved were Staphylococcus aureus (49.6% of infections), Staphylococcus epidermidis (10.4%), Serratia marcescens (10.4%), Pseudomonas aeruginosa (9.6%), and Enterococcus faecalis/fecum (8.7%). None of these was found in ≥1% of HOMD clone libraries, indicating that they very rarely colonize the teeth or plaque.
CONCLUSIONS
Most VAIs were associated with microorganisms more likely to originate from other body sites than from the oral cavity. The risk of a VAI being caused by microorganisms originating from the oral cavity is very small.
目的
本研究旨在评估血液透析患者血管通路相关感染（VAIs）相关的微生物，特别是可能源自口腔的微生物。
研究设计
对接受了 10 年治疗的血液透析患者的 VAIs 相关微生物进行了回顾性和比较分析，并与人类口腔微生物组数据库（HOMD）进行了对比。
结果
在确定的 218 例患者记录中，共有 65 例患者共发生 115 次 VAI 发作。最常见的感染微生物包括金黄色葡萄球菌（49.6%）、表皮葡萄球菌（10.4%）、粘质沙雷氏菌（10.4%）、铜绿假单胞菌（9.6%）和粪肠球菌/屎肠球菌（8.7%）。这些微生物在 HOMD 克隆文库中的占比均未超过 1%，这表明它们很少定植于牙齿或牙菌斑。
结论
大多数 VAI 与更可能源自其他身体部位而非口腔的微生物相关。源自口腔的微生物引起 VAI 的风险非常小。
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