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作为免疫功能低下合并透析患者菌血症的一种新兴致病原——病例报告

as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients-A Case Report.

作者信息

Vergov Bozhidar, Angelova Andreana, Baldzhieva Alexandra, Kalchev Yordan, Tsochev Georgi, Murdjeva Marianna

机构信息

Department of Medical Biology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.

Department of Dialysis Treatment, St George University Hospital, 6000 Plovdiv, Bulgaria.

出版信息

Healthcare (Basel). 2023 Jul 19;11(14):2059. doi: 10.3390/healthcare11142059.

Abstract

Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious agent-. In recent years, the incidence of spp. infections in immunocompromised patients with central venous catheters (CVC) has appeared to rise. The isolation and identification of spp. are challenging and require modern techniques. In addition, the treatment is usually persistent and often results in CVC extraction, which is associated with further risk and costs for the patient. We also studied the alterations in the immune status of the patient caused by long-term renal replacement therapy and persistent hepatitis C virus infection. Antibiotic therapy and immunostimulation with Inosine pranobex lead to successful eradication of the infection without the need for CVC replacement.

摘要

医疗护理的改善已将严重疾病转变为慢性疾病,但通常其治疗和医疗设备的使用与特定并发症相关。在此,我们展示了一例长期透析患者感染罕见机会性感染病原体的临床病例。近年来,免疫功能低下且带有中心静脉导管(CVC)的患者中 spp. 感染的发生率似乎有所上升。spp. 的分离和鉴定具有挑战性,需要现代技术。此外,治疗通常具有持久性,且常常导致拔除 CVC,这会给患者带来进一步的风险和费用。我们还研究了长期肾脏替代治疗和持续丙型肝炎病毒感染对患者免疫状态的改变。抗生素治疗和使用肌苷 pranobex 进行免疫刺激成功根除了感染,无需更换 CVC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/259e/10379339/1237b14354c1/healthcare-11-02059-g001.jpg

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