p53/p63 靶基因 PERP 的缺失是口腔癌发生的早期事件，与局部复发率升高相关。
Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse.
机构信息
Department of Pathology, Stanford University, Stanford, California 94305-5324, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):95-103. doi: 10.1016/j.oooo.2012.10.017.
Abstract
BACKGROUND
PERP is a p53/p63-regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression.
STUDY DESIGN
We evaluated PERP expression in different grades of oral dysplasia (34 cases) and at different stages of invasive squamous cell carcinoma (SCC), and correlated the latter with clinical outcome. A tissue microarray consisting of nondysplastic mucosa, carcinoma in situ, SCC, and nodal metastases from 33 patients with human papilloma virus-negative SCC was stained for PERP and E-cadherin.
RESULTS
Complete loss of PERP expression was associated with worse local control in patients with SCC. The 5-year local control rate was 91% for patients with partial PERP loss versus 31% for those with complete loss (P = .01).
CONCLUSIONS
This is the first study to show that loss of PERP expression correlates with the transition to SCC and with increased local relapse in patients with oral cavity SCC.
摘要
背景
PERP 是一个由 p53/p63 调控的基因，编码一种桥粒蛋白，在细胞间黏附及肿瘤抑制中发挥关键作用。
研究设计
我们评估了不同分级的口腔异型增生（34 例）和浸润性鳞状细胞癌（SCC）不同阶段中 PERP 的表达，并与临床结果进行了相关性分析。通过对 33 例 HPV 阴性 SCC 患者的非异型增生黏膜、原位癌、SCC 和淋巴结转移的组织微阵列进行 PERP 和 E-钙黏蛋白染色。
结果
在 SCC 患者中，完全缺失 PERP 表达与局部控制不良相关。部分 PERP 缺失患者的 5 年局部控制率为 91%，而完全缺失患者的局部控制率为 31%（P=.01）。
结论
这是首个表明 PERP 表达缺失与 SCC 转化以及口腔 SCC 患者局部复发增加相关的研究。
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