Department of Ophthalmology, University of Brescia, Brescia, Italy.
Surv Ophthalmol. 2013 Jan-Feb;58(1):26-41. doi: 10.1016/j.survophthal.2012.05.003.
This review analyzes the currently available literature on circadian rhythms of intraocular pressure (IOP), blood pressure, and calculated ocular perfusion pressure (OPP) in patients with open-angle glaucoma. Although adequately powered, prospective trials are not available. The existing evidence suggests that high 24-hour IOP and OPP fluctuations can have detrimental effects in eyes with glaucoma. The currently emerging continuous IOP monitoring technologies may soon offer important contributions to the study of IOP rhythms. Once telemetric technologies become validated and widely available for clinical use, they may provide an important tool towards a better understanding of long- and short-term IOP fluctuations during a patient's daily routine. Important issues that need to be investigated further include the identification of appropriate surrogate measures of IOP and OPP fluctuation for patients unable to undergo 24-hour measurements, the determination of formulae that best describe the relationship between systemic blood pressure and IOP with OPP, and the exact clinical relevance of IOP and OPP fluctuation in individual patients. Despite the unanswered questions, a significant body of literature suggests that OPP assessment may be clinically relevant in a significant number of glaucoma patients.
这篇综述分析了目前关于开角型青光眼患者眼压（IOP）、血压和计算得出的眼内灌注压（OPP）的昼夜节律的文献。尽管有足够的研究，但目前还没有前瞻性试验。现有证据表明，高 24 小时 IOP 和 OPP 波动可能对青光眼眼产生不利影响。目前新兴的连续眼压监测技术可能很快会对 IOP 节律的研究做出重要贡献。一旦遥测技术得到验证并广泛应用于临床，它们可能为更好地了解患者日常活动中的长期和短期 IOP 波动提供重要工具。需要进一步研究的重要问题包括为无法进行 24 小时测量的患者确定 IOP 和 OPP 波动的适当替代指标，确定最能描述全身血压与 IOP 和 OPP 之间关系的公式，以及 IOP 和 OPP 波动在个体患者中的具体临床相关性。尽管存在未解答的问题，但大量文献表明，OPP 评估在许多青光眼患者中可能具有临床相关性。
