Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065, USA.
Virology. 2013 Jan 5;435(1):70-80. doi: 10.1016/j.virol.2012.09.044.
Hepatitis C virus (HCV) is a major causative agent of severe liver disease including fibrosis, cirrhosis and liver cancer. Therapy has improved over the years, but continues to be associated with adverse side effects and variable success rates. Furthermore, a vaccine protecting against HCV infection remains elusive. Development of more effective intervention measures has been delayed by the lack of a suitable animal model. Naturally, HCV infects only humans and chimpanzees. The determinants of this limited host range are poorly understood in part due to difficulties of studying HCV in cell culture. Some progress has been made elucidating the barriers for the HCV lifecycle in non-permissive species which will help in the future to construct animal models for HCV infection, immunity and pathogenesis.
丙型肝炎病毒（HCV）是严重肝脏疾病（包括纤维化、肝硬化和肝癌）的主要致病因子。多年来，治疗方法有所改善，但仍存在不良反应和成功率差异等问题。此外，预防 HCV 感染的疫苗仍难以实现。由于缺乏合适的动物模型，更有效的干预措施的开发一直受到阻碍。自然情况下，HCV 仅感染人类和黑猩猩。由于在细胞培养中研究 HCV 存在困难，导致部分原因是对这种有限宿主范围的决定因素了解甚少。在阐明非允许物种中 HCV 生命周期的障碍方面已经取得了一些进展，这将有助于未来构建 HCV 感染、免疫和发病机制的动物模型。
