一种新出现的丙型肝炎病毒小鼠模型。
A new HCV mouse model on the block.
作者信息
Tawar Rajiv G, Mailly Laurent, Baumert Thomas F
机构信息
1] Inserm, U1110, Strasbourg, France [2] Université de Strasbourg, Strasbourg, France.
1] Inserm, U1110, Strasbourg, France [2] Université de Strasbourg, Strasbourg, France [3] Pôle Hépato-digestif, Institut Hospitalo-Universitaire, Strasbourg, France.
出版信息
Cell Res. 2014 Oct;24(10):1153-4. doi: 10.1038/cr.2014.126. Epub 2014 Sep 26.
Abstract
The investigation of virus-induced liver disease and hepatocellular carcinoma needs small animal models modeling hepatitis C virus (HCV) infection and liver disease biology. A recent study published in Cell Research reports a novel mouse model which is permissive for chronic HCV infection and shows chronic liver injury including inflammation, steatosis and fibrosis.
摘要
对病毒诱导的肝病和肝细胞癌的研究需要能够模拟丙型肝炎病毒（HCV）感染及肝病生物学特性的小动物模型。发表于《细胞研究》的一项近期研究报告了一种新型小鼠模型，该模型可允许慢性HCV感染，并呈现出包括炎症、脂肪变性和纤维化在内的慢性肝损伤。
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本文引用的文献
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Cell Res. 2014 Sep;24(9):1050-66. doi: 10.1038/cr.2014.116. Epub 2014 Aug 26.
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