Department of Signal Transduction, Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Cell. 2012 Dec 7;151(6):1155-6. doi: 10.1016/j.cell.2012.11.020.
The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.
肿瘤代谢的重编程被认为是由于指导细胞生长的信号通路的过度激活所致。Sebastian 等人表明，肿瘤抑制因子 SIRT6 的缺失通过激活肿瘤代谢来转化细胞。这一过程独立于经典生长信号通路的突变发生，并揭示了肿瘤代谢在肿瘤发生中的致癌作用。
