Costa Adilson, Pegas Pereira Elisangela Samartin, de Oliveira Pereira Margareth, Calixto dos Santos Felipe Borba, Favaro Raquel, Stocco Paula Luz, Fávaro de Arruda Lúcia Helena
Pontifitial Catholic University of Campinas, Campinas/SP, Brazil.
Dermatol Online J. 2012 Nov 15;18(11):2.
Diffusion halo profiles of different commercially available type-A botulinum toxins (BTX-A) have been studied.
To evaluate and compare the largest diameter of diffusion halos of 5 different doses of 5 different commercially available BTX-A.
Twenty-five adult female volunteers were included. Products with 100 units (100 UI) and the product with 500 units (500 UI) were reconstituted in a ratio of 1:2.5. Products were applied in five different concentrations (1 U/2.5 U, 2 U/5 U, 3 U/7.5 U, 4 U/10 U, and 5 U/12.5 U). After 30 days, a starch-iodine test was conducted to obtain the largest diameter of each halo.
For all BTX-As, the higher the number of units used, the larger the diameter of the diffusion halo p<0.05). Statistically significant differences (p<0.05) were observed between the North American and Chinese BTX-As for the three lowest doses, between the Korean and German BTX-As for all doses, between the French and Chinese BTX-As for the four highest doses, between the French and German BTX-As for all doses, between the Chinese and German BTX-As for the four highest doses, and between the North American and German BTX-As for all doses (p<0.01).
Differences were observed between all brands of BTX-As and between the different doses of each brand.
已对不同市售A型肉毒杆菌毒素（BTX-A）的扩散晕圈轮廓进行了研究。
评估并比较5种不同市售BTX-A的5种不同剂量的扩散晕圈最大直径。
纳入25名成年女性志愿者。将100单位（100 UI）的产品和500单位（500 UI）的产品按1:2.5的比例复溶。以五种不同浓度（1 U/2.5 U、2 U/5 U、3 U/7.5 U、4 U/10 U和5 U/12.5 U）应用产品。30天后，进行淀粉碘试验以获得每个晕圈的最大直径。
对于所有BTX-A，使用的单位数量越高，扩散晕圈的直径越大（p<0.05）。在北美和中国的BTX-A之间，对于三种最低剂量，在韩国和德国的BTX-A之间，对于所有剂量，在法国和中国的BTX-A之间，对于四种最高剂量，在法国和德国的BTX-A之间，对于所有剂量，在中国和德国的BTX-A之间，对于四种最高剂量，以及在北美和德国的BTX-A之间，对于所有剂量，均观察到统计学上的显著差异（p<0.01）。
在所有品牌的BTX-A之间以及每个品牌的不同剂量之间均观察到差异。
