Instituto de Assistência Médica ao Servidor Público, São Paulo, SP, Brazil.
Department of Dermatology, Pontifical Catholic University of Campinas, Campinas, SP, Brazil.
Aesthet Surg J. 2019 Aug 22;39(9):993-1004. doi: 10.1093/asj/sjy207.
Excessive sweating is a clinical condition that can be improved with type-A botulinum toxin (BTX-A).
To evaluate and compare the largest diameter of sweating inhibition halo (SIH) of 5 different commercially available BTX-A, in five different doses, in a 6-month-long clinical evaluation.
Twenty-five adult female volunteers were injected in the dorsal trunk area with both 100 units (100UI) and 500 units (500UI) BTX-A products, reconstituted in a ratio of 1:2.5 IU, respectively. Products were applied in five different concentrations (1:2.5U, 2:5U, 3:7.5U, 4:10U, and 5:12.5U). After 30, 60, 90, 120, 150, and 180 days, a starch-iodine test was performed to obtain the largest diameter of each SIH.
The higher the number of units used, the larger the SIH p < 0.05 for all BTX-A. However, Botox®, Botulift®, Dysport®, and Prosigne® have pretty likewise SIH along the study, with some few differences for some doses and months between one and another. However, Xeomin® is the BTX-A with the smallest SIH, in comparison with all others, in any dose and period.
Differences were observed among all brands of BTX-As, based on dose and time after injection. Xeomin® provides the smallest SIH in comparison with others BTX-A.
多汗症是一种可以通过 A 型肉毒毒素（BTX-A）改善的临床病症。
评估和比较 5 种不同市售 BTX-A 在 6 个月临床评估中，以 5 种不同剂量产生的最大抑制出汗晕（SIH）直径。
25 名成年女性志愿者在背部躯干区域分别注射 100 单位（100UI）和 500 单位（500UI）BTX-A 产品，按 1:2.5IU 的比例配制。产品分别以 5 种不同浓度（1:2.5U、2:5U、3:7.5U、4:10U 和 5:12.5U）应用。在 30、60、90、120、150 和 180 天后，进行淀粉-碘试验以获得每个 SIH 的最大直径。
使用的单位数量越高，SIH 越大（p<0.05），所有 BTX-A 均如此。然而，Botox®、Botulift®、Dysport®和 Prosigne®在整个研究期间的 SIH 非常相似，在同一品牌的不同剂量和月份之间存在一些差异。然而，与其他所有 BTX-A 相比，Xeomin®的 SIH 最小，无论剂量和时间如何。
根据注射后剂量和时间，观察到所有 BTX-A 品牌之间存在差异。与其他 BTX-A 相比，Xeomin®提供的 SIH 最小。
