Koshelev Misha Vladislavovich, Fleming Kristy F, Grekin Sarah J, Wasko Carina A
MSTP Program, Baylor College of Medicine, Houston, Texas, USA.
Dermatol Online J. 2012 Nov 15;18(11):10.
Fixed drug eruptions (FDEs), first described by Bourns in 1889, are solitary or multiple, sharply demarcated, round to oval, edematous and erythematous patches that arise after exposure to a specific medication. They can be pink to dark red to brown and can be larger than 10 cm in size. In almost a third of patients in some case series, these lesions have been reported to progress to vesicles or bullae. Fixed drug eruptions have been associated in up to 40 percent of cases with non-steroidal inflammatory drugs, including ibuprofen. We describe an interesting case of a biopsy-confirmed FDE that presented as large bullae on the posterior thigh after ibuprofen use.
固定性药疹（FDEs）于1889年由伯恩斯首次描述，是在接触特定药物后出现的单发或多发、边界清晰、圆形至椭圆形、水肿性红斑斑块。颜色可为粉红色至暗红色再至棕色，大小可超过10厘米。在一些病例系列中，近三分之一的患者报告这些皮损会发展为水疱或大疱。高达40%的固定性药疹病例与非甾体类抗炎药有关，包括布洛芬。我们描述了一例经活检确诊的固定性药疹的有趣病例，该病例在使用布洛芬后大腿后部出现大水疱。
