Michaud M, Gaudin C, Brechemier D, Moulis G, Astudillo L, Lavialle-Guillotreau V, Balardy L
Service de médecine interne, hôpital de Purpan, CHU de Toulouse, Toulouse, France.
Rev Med Interne. 2013 Mar;34(3):171-3. doi: 10.1016/j.revmed.2012.10.374. Epub 2012 Dec 4.
Thymomas, benign or malignant, may be associated with autoimmune diseases. They are classically associated with myasthenia gravis, neuromyotonia, or pure red cell aplasia.
We here report, to the best of our knowledge, the first description of an association between thymoma and Reynolds syndrome (systemic sclerosis associated with primary biliary cirrhosis) in an 80-year-old woman.
The suspected pathogenesis of this association could be a thymus escape of auto-reactive T lymphocytes and the consecutive development of an auto-immune disorder.
胸腺瘤，无论良性或恶性，都可能与自身免疫性疾病相关。它们典型地与重症肌无力、神经性肌强直或纯红细胞再生障碍相关。
据我们所知，我们在此报告了一名80岁女性胸腺瘤与雷诺综合征（与原发性胆汁性肝硬化相关的系统性硬化症）之间关联的首次描述。
这种关联的疑似发病机制可能是自身反应性T淋巴细胞的胸腺逃逸以及自身免疫性疾病的后续发展。
