Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Ann Thorac Surg. 2014 May;97(5):1802-4. doi: 10.1016/j.athoracsur.2013.07.103.
Stiff-person syndrome (formerly known as stiff-man syndrome) is a very rare autoimmune and neurogenic disorder, thought to present as a paraneoplastic variant in association with thymoma. Pure red blood cell aplasia is also a paraneoplastic disorder associated with thymoma. Although separate cases of stiff-person syndrome and pure red blood cell aplasia have been reported, we describe here what is to our knowledge the first case of recurrent thymoma with both stiff-person syndrome and pure red blood cell aplasia. We describe the successful treatment of the neurogenic symptoms of stiff-person syndrome and the progressive anemia associated with pure red blood cell aplasia by tumor excision.
僵人综合征（以前称为僵人综合征）是一种非常罕见的自身免疫性和神经源性疾病，据认为与胸腺瘤有关，表现为副肿瘤变异型。纯红细胞再生障碍性贫血也是一种与胸腺瘤相关的副肿瘤疾病。虽然已有单独的僵人综合征和纯红细胞再生障碍性贫血病例报告，但我们在此描述的是据我们所知首例复发性胸腺瘤同时伴僵人综合征和纯红细胞再生障碍性贫血。我们描述了通过肿瘤切除成功治疗僵人综合征的神经症状和与纯红细胞再生障碍性贫血相关的进行性贫血。
