Silverman B, James C, Misra S, Schneider A T, Chiaramonte L T
Department of Allergy and Immunology, Long Island College Hospital, Brooklyn, New York.
Ann Allergy. 1990 Apr;64(4):373-5.
Ten asthmatics selected for their tendency to experience frequent acute exacerbations were instructed in peak flow measurement. Each subject then recorded estimated peak flow (EPF) and measured peak flow (PF) at home twice daily. Data for up to 56 consecutive observations (4 weeks) per subject were analyzed. The correlation coefficient between EPF and PF following PF drops of 15% was .993 overall and was not significantly different following PF drops even greater than 25%. The absolute and proportional differences between PF and EPF were also not significantly affected by the magnitude of PF drop but decreased over time indicating improved accuracy of estimates with practice. Asthmatics can be trained to estimate accurately acute drops in airflow. Such ability has not been demonstrated in prior studies which utilized verbal symptom reports as indicators of subjective perception of airflow. Accurate perception would be a useful aid in achieving early recognition of acute exacerbations and in improving medication compliance. It is an adjunct to regular peak flow measurement, not a substitute for it.
选取了10名有频繁急性加重倾向的哮喘患者,指导他们进行呼气峰流速测量。然后,每位受试者每天在家中两次记录估计呼气峰流速(EPF)和测量呼气峰流速(PF)。分析了每位受试者连续多达56次观察(4周)的数据。PF下降15%后,EPF与PF之间的相关系数总体为0.993,PF下降甚至超过25%后,该相关系数也无显著差异。PF与EPF之间的绝对差异和比例差异也未受到PF下降幅度的显著影响,但随时间推移而减小,表明随着练习,估计的准确性有所提高。哮喘患者可以通过训练准确估计气流的急性下降。这种能力在先前利用言语症状报告作为气流主观感知指标的研究中尚未得到证实。准确的感知将有助于早期识别急性加重并提高药物依从性。它是常规呼气峰流速测量的辅助手段,而非替代品。