Silverman B A, Mayer D, Sabinsky R, Williams-Akita A, Feldman J, Schneider A T, Chiaramonte L T
Department of Allergy and Immunology, Long Island College Hospital, Brooklyn, NY.
Ann Allergy. 1987 Nov;59(5):350-4.
Eighteen asthmatics, aged 7 to 43, rated their breathing on a scale of 0 to 5 (worst to best). They were then informed of their predicted normal peak expiratory flow rate (PEFR) and instructed in proper PEFR measurement. Each subject then estimated and measured PEFR under physician supervision and subsequently rated breathing, estimated and measured PEFR at home twice daily recording the observations. At the initial home observation, the correlation coefficient (r1) between estimated and measured PEFR was .98. After ten observations r1 was greater than or equal to .97 in all 18 subjects (group mean .99). The r1 remained unchanged in those subjects who completed 28 and 42 observations. The r1 was .98 when only the observations where measured PEFR was less than 20% predicted were considered, demonstrating the validity of the relationship during abnormal expiratory flow. Multiple regression analysis showed no significant trend in the difference between estimated and measured PEFR over time after the initial observation. Of 12 subjects, 4 were significant underestimators of PEFR and 3 were overestimators, but the magnitude of either tendency was relatively small. The correlation coefficient (r2) between a subjective verbal breathing score and measured PEFR ranged from -.23 to .92 on an individual basis over the three time periods, with statistically significant group mean values of .37, .39, and .45 at 10, 28, and 42 observations, respectively. The r2 for observations where measured PEFR was abnormal was only .14 and not significant.(ABSTRACT TRUNCATED AT 250 WORDS)
18名年龄在7至43岁之间的哮喘患者,按照0至5分的标准(最差至最佳)对自己的呼吸状况进行评分。随后告知他们预测的正常呼气峰值流速(PEFR),并指导他们正确测量PEFR。然后,每位受试者在医生的监督下估算并测量PEFR,随后对呼吸状况进行评分,在家中每天两次估算并测量PEFR,并记录观察结果。在首次在家中观察时,估算的PEFR与测量的PEFR之间的相关系数(r1)为0.98。经过十次观察后,所有18名受试者的r1均大于或等于0.97(组均值为0.99)。在完成28次和42次观察的受试者中,r1保持不变。当仅考虑测量的PEFR低于预测值20%的观察结果时,r1为0.98,这表明在异常呼气流量期间这种关系的有效性。多元回归分析显示,在首次观察后,估算的PEFR与测量的PEFR之间的差异随时间没有显著趋势。在12名受试者中,4名对PEFR的估算明显偏低,3名偏高,但两种趋势的幅度都相对较小。在三个时间段内,主观言语呼吸评分与测量的PEFR之间的相关系数(r2)在个体层面上介于-0.23至0.92之间,在10次、28次和42次观察时,组均值分别为0.37、0.39和0.45,具有统计学意义。测量的PEFR异常时的r2仅为0.14,无统计学意义。(摘要截选至250字)