CPFRR, ERCPSP, School of Light Industry and Food Engineering South China University of Technology, Guangzhou 510640, China.
Carbohydr Polym. 2013 Jan 30;92(1):455-61. doi: 10.1016/j.carbpol.2012.09.048. Epub 2012 Oct 2.
Blends of gelatin with up to 50% hydroxypropylated high amylose (80%) corn starch were developed as capsule materials. Poly(ethylene glycol) (PEG) was used as both a plasticizer and a compatibilizer in the blends. In order to prepare hard capsules for pharmaceutical applications using the well-established method of dipping stainless steel mold pins into solution, solutions with higher solids concentrations (up to 30%) were developed. The solutions, films and capsules of the different gelatin-starch blends were characterized by viscosity, transparency, tensile testing, water contact angle and SEM. The linear microstructure of the high amylose starch, and the flexible and more hydrophilic hydroxylpropylene groups grafted onto the starch improved the compatibility between the gelatin and starch. SEM revealed a continuous phase of gelatin on the surface of films from all blends. The water contact angle of pure gelatin and the different blends were similar, indicating a continuous phase of gelatin. By optimizing temperature and incubation time to control viscosity, capsules of various blends were successfully developed. PEG increased the transparency and toughness of the various blends.
将高达 50%羟丙基高直链淀粉（80%）玉米淀粉与明胶混合，用作胶囊材料。聚乙二醇（PEG）在混合物中既作为增塑剂又作为相容剂。为了使用成熟的不锈钢模具针浸入溶液的方法制备用于制药应用的硬胶囊，开发了具有更高固含量（高达 30%）的溶液。通过粘度、透明度、拉伸测试、水接触角和 SEM 对不同明胶-淀粉混合物的溶液、薄膜和胶囊进行了表征。高直链淀粉的线性微观结构，以及接枝到淀粉上的柔韧性和亲水性羟丙基基团改善了明胶和淀粉之间的相容性。SEM 显示，所有混合物的薄膜表面都有明胶的连续相。纯明胶和不同混合物的水接触角相似，表明有明胶的连续相。通过优化温度和孵育时间来控制粘度，成功开发了各种混合物的胶囊。PEG 提高了各种混合物的透明度和韧性。
