Department of Carbohydrates and Cereals, Institute of Chemical Technology in Prague, Technická 5, 166 28 Prague 6 Dejvice, Czech Republic.
Carbohydr Polym. 2013 Jan 30;92(1):792-809. doi: 10.1016/j.carbpol.2012.09.077. Epub 2012 Oct 9.
Fungal glucans represent various structurally different d-glucose polymers with a large diversity of molecular mass and configuration. According to glucose anomeric structure, it is possible to distinguish α-D-glucans, β-D-glucans and mixed α,β-D-glucans. Further discrimination could be made on the basis of glycosidic bond position in a pyranoid ring, distribution of specific glycosidic bonds along a chain, branching and molecular mass. Fungal glucans can be chemically modified to obtain various derivatives of potential industrial or medicinal importance. NMR spectroscopy is a powerful tool in structural analysis of fungal glucans. Together with chemolytic methods like methylation analysis and periodate oxidation, NMR is able to determine exact structure of these polysaccharides. Fungal glucans or their derivatives exert various biological activities, which are usually linked to structure, molecular mass and substitution degree.
真菌葡聚糖是一类具有不同结构的 d-葡萄糖聚合物，其分子量和构型存在很大差异。根据葡萄糖的端基异构结构，可以将其分为 α-D-葡聚糖、β-D-葡聚糖和混合的 α，β-D-葡聚糖。进一步的区分可以基于吡喃环中糖苷键的位置、链上特定糖苷键的分布、支化和分子量。真菌葡聚糖可以进行化学修饰，以获得具有潜在工业或药用重要性的各种衍生物。NMR 光谱是真菌葡聚糖结构分析的有力工具。与甲基化分析和高碘酸盐氧化等化学裂解方法相结合，NMR 能够确定这些多糖的精确结构。真菌葡聚糖或其衍生物具有各种生物活性，这些活性通常与结构、分子量和取代度有关。
