Department of Molecular Biology, BK21 Graduate Program for RNA Biology, Dankook University, Yongin 448-701, Republic of Korea.
J Plant Physiol. 2013 Mar 15;170(5):529-33. doi: 10.1016/j.jplph.2012.11.001. Epub 2012 Dec 4.
Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are core factors in driving vesicle fusion with target membranes, which is critical in eukaryotes having distinct subcellular organelles. Amongst them, vesicle-associated membrane proteins (VAMP) 721 and 722 are involved in plant growth/development and immunity. In the course of stress responses, plants often show retarded growth. The precise mechanism of this retardation is not fully understood. The plant stress hormone abscisic acid (ABA), which can cause growth inhibition, down-regulates VAMP721/722 protein levels but not transcript levels. Enhanced growth inhibition and early depletion of the amount of VAMP721/722 caused by ABA in haploinsufficient VAMP721(+/-)VAMP722(-/-) and VAMP721(-/-)VAMP722(+/-) plants suggest that ABA impedes plant growth in part by reducing VAMP721/722 proteins. Since VAMP721/722 are engaged in exocytosis, our data implies that ABA-induced growth retardation may result from diminished secretory activities leading to decreased transport of molecules required for plant growth in the plasma membrane and cell wall.
可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）蛋白是驱动囊泡与靶膜融合的核心因子，这在具有不同亚细胞细胞器的真核生物中至关重要。其中，囊泡相关膜蛋白（VAMP）721 和 722 参与植物生长/发育和免疫。在应激反应过程中，植物的生长通常会受到抑制。这种抑制的精确机制尚未完全理解。植物应激激素脱落酸（ABA）可引起生长抑制，下调 VAMP721/722 蛋白水平但不影响转录水平。在 VAMP721(+/-)VAMP722(-/-)和 VAMP721(-/-)VAMP722(+/-)杂合不足植物中，ABA 引起的增强的生长抑制和 VAMP721/722 数量的早期耗竭表明，ABA 部分通过减少 VAMP721/722 蛋白来阻碍植物生长。由于 VAMP721/722 参与胞吐作用，我们的数据表明，ABA 诱导的生长迟缓可能是由于分泌活动减少导致质膜和细胞壁中植物生长所需分子的运输减少所致。
